Valores de referência hematológicos e bioquímicos de ratos  (Rattus novergicus linhagem Wistar) provenientes do biotério da  Universidade Tiradentes

Claudio Moreira Lima; Adriana Karla Lima; Marcelia G. Dória Melo; Grace Anne Azevedo Dória; Mairim Russo Serafini; Ricardo Luiz Cavalcante Albuquerque-Júnor; Adriano Antunes Souza Araújo

Reference values of the hematological and biochemical parameters in the rats (Rattus novergicus Wistar) from the vivarium of the University Tiradentes

Authors

Claudio Moreira Lima Universidade Federal de Sergipe
Adriana Karla Lima Universidade Tiradentes
Marcelia G. Dória Melo Universidade Federal de Sergipe
Grace Anne Azevedo Dória Universidade Federal de Sergipe
Mairim Russo Serafini Universidade Federal de Sergipe
Ricardo Luiz Cavalcante Albuquerque-Júnor Universidade Tiradentes
Adriano Antunes Souza Araújo Universidade Federal de Sergipe

Keywords:

reference values, biochemistry profile, hematological profile

Abstract

The various physiological parameters of laboratory animals may diversify between different strains of a given species but also by intrisec and extrinsic factors. Therefore, it is imperative that each Research Center to establish reference values for animals according to the species, the diet, the lineage, the sex and age as well as the methodology used to analyze the parameters. The aim of this study was to determine the range of reference values for hematologic and biochemical parameters of non-treated animals from the University Tiradentes vivarium, Sergipe, Brazil. Healthy Wistar rats were used (140-310 g) of both genders. The hematological profile (leukocytes: total and differential, RBC, hemoglobin, hematocrit, some hematological indexes and platelets) and serum biochemistry determination of several parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total protein, albumin, globulin, urea, creatinine, glucose, total cholesterol, triglycerides, uric acid, potassium, sodium, chloride, gamma-GT, calcium) were evaluated. Research data provide reference values for creation of Wistar rats, thus contributing to several projects of experimental research.

Author Biography

Claudio Moreira Lima, Universidade Federal de Sergipe

Núcleo de Pós graduação da Saúde

Departamento de Farmácia

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Published

2014-04-07

How to Cite

Lima, C. M., Lima, A. K., Melo, M. G. D., Dória, G. A. A., Serafini, M. R., Albuquerque-Júnor, R. L. C., & Araújo, A. A. S. (2014). Reference values of the hematological and biochemical parameters in the rats (Rattus novergicus Wistar) from the vivarium of the University Tiradentes. Scientia Plena, 10(3). Retrieved from https://scientiaplena.org.br/sp/article/view/1784

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Issue

Vol. 10 No. 3 (2014): March/Março 2014

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Articles

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