Lack of antidiabetic activity of the methanol extract of Costus spicatus in rats

Authors

  • Gabriela Oliveira Silveira Universidade Federal de Sergipe
  • Ana Paula Oliveira Barbosa Universidade Federal de Sergipe
  • Marilia Trindade Santana Universidade Federal de Sergipe
  • Lucindo José Quintans-Júnior Universidade Federal de Sergipe
  • Damião Pergentino De Souza Universidade Federal de Sergipe
  • José Melquiades Resende-Neto Universidade Tiradentes
  • Rogéria de Souza Nunes Universidade Federal de Sergipe
  • Marcio Roberto Viana Santos Universidade Federal de Sergipe

Abstract

Costus spicatus (Costaceae), popularly known as "cana-do-brejo" in folk medicine is used as a diuretic, for urinary tract infections and as antidiabetic agent. The aim of the present work was to evaluate the antidiabetic activity potential of the methanol extract os Costus spicatus (MECS) in rats. The antihyperglycemic effect was evaluated in normoglycemic male Wistar rats (150-200 g). These animals were divided into five groups of five animals each and were treated orally with saline solution (0.9%), metformin 500 mg/kg (reference drug) or MECS at the doses of 100, 200, and 400 mg/kg. After treatments, animals received orally glucose (3g/Kg) and their blood glucose levels were measured during 120 min. The average blood glucose before treatment was 82 ± 2 mg/dL. Metformin was able to inhibit significantly the hyperglycemia after glucose administration. However, these effects were not observed with MECS. In order to evaluate the hypoglycemic activity MECS was tested in alloxan-induced diabetic rats. These animals showed average fasting blood glucose of 453 ± 14 mg/dL. Metformin was able to reduce 51 ± 11% glucose levels in diabetic rats, however, MECS not showed significantly effect. In conclusion, these results suggest that methanol extract obtained from Costus spicatus leaves not presents antidiabetic activity, at least in the experimental model tested in this study. Other experiments are required to confirm these results.

Author Biographies

Gabriela Oliveira Silveira, Universidade Federal de Sergipe

Departamento de Fisiologia

Ana Paula Oliveira Barbosa, Universidade Federal de Sergipe

Departamento de Fisiologia

Marilia Trindade Santana, Universidade Federal de Sergipe

Deparatamento de Fisiologia

Lucindo José Quintans-Júnior, Universidade Federal de Sergipe

Departamento de Fisiologia

Damião Pergentino De Souza, Universidade Federal de Sergipe

Departamento de Fisiologia

José Melquiades Resende-Neto, Universidade Tiradentes

Departamento de farmácia

Rogéria de Souza Nunes, Universidade Federal de Sergipe

Departamento de Fisiologia

Marcio Roberto Viana Santos, Universidade Federal de Sergipe

Departamento de Fisiologia

Published

2011-01-12

How to Cite

Silveira, G. O., Barbosa, A. P. O., Santana, M. T., Quintans-Júnior, L. J., De Souza, D. P., Resende-Neto, J. M., … Santos, M. R. V. (2011). Lack of antidiabetic activity of the methanol extract of Costus spicatus in rats. Scientia Plena, 6(12(A). Retrieved from https://scientiaplena.org.br/sp/article/view/143

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