Characterization of clonidine in liposomal formulation

Authors

  • R. S. Nunes Laboratório de Farmacotécnica, Universidade Federal de Sergipe
  • J. R. Azevedo Laboratório de Farmacotécnica, Universidade Federal de Sergipe
  • N. L. Pereira Programa de Pós-graduação em fármacos e medicamentos da Universidade de São Paul

Keywords:

liposomal formulation, clonidine, drug release

Abstract

Many researchers in the last four decades have been devoted to the development of drug-delivery systems. Since its first application many results have been obtained especially in manipulation of carriers and their interaction with encapsulated drugs. Liposomes are among the most important carriers. Liposomes have the ability to encapsulation of drugs  of variety nature. In this study, we characterized the encapsulation and delivery of clonidine in liposomal systems. The stable entraped efficacy of clonidine was of 40%. The release profile of clonidine in formulation werw quantified. The formulation release 20,40% in 8h. These value was compared to the clonidine release in solution, which was of 37,8% in 8h. Proposed formulations provided stable percentage of entrapped drug and drug modification release.

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How to Cite

Nunes, R. S., Azevedo, J. R., & Pereira, N. L. (2011). Characterization of clonidine in liposomal formulation. Scientia Plena, 1(7). Retrieved from https://scientiaplena.org.br/sp/article/view/584

Issue

Vol. 1 No. 7 (2005): October/Outubro 2005

Section

Articles

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