Antibacterial activity of the ethanolic extract of Brazilian red propolis against multidrug-resistant extended-spectrum β-lactamase and carbapenemase-producing bacteria
DOI:
https://doi.org/10.14808/sci.plena.2023.044501%20Keywords:
antibacterial, propolis, folk medicineAbstract
Propolis is a resinous product derived from honeybees and has been widely used by folk medicine throughout the years for several purposes. A wide biological potential has been attributed to the use of Brazilian red propolis, especially its antimicrobial activity which represents the mean of protection of honeybees against microbial pathogens. This study aimed to assess the in vitro antibacterial activity of the ethanolic extract of Brazilian red propolis produced by Apis mellifera against multidrug-resistant bacteria, acquired from hospital infections. Five Escherichia coli isolates and seven Klebsiella pneumoniae ones were used in this study, all of them presented either ESBL and/or KPC phenotypes. In vitro antimicrobial assay was performed by microdilution method. The minimum inhibitory and bactericidal concentrations (MIC and MBC) of the ethanolic extract of red propolis were determined for each bacterial strain and exhibited bacteriostatic and bactericidal activities against multi-drug resistant strains of E. coli and K. pneumoniae, presenting MIC of 2.05 and 0.13 mg/mL and MBC of 15.63 and 3.91 mg/mL, respectively. These results confirmed the antibacterial activity of the Brazilian red propolis against multidrug-resistant strains, highlighting its use as a potential therapeutic target for adjuvant treatment of multidrug-resistant bacterial infections.
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Copyright (c) 2023 Alberto de Lima Xavier, Narcisa Caroline de Oliveira Silva, Rogério Ribeiro Soares, Sheila Abreu, Emerson Alves de Araújo, Jorge Belem Oliveira Júnior, Ana Beatriz Sotero Siqueira
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