Evaluation of antifungal activity of semisolid formulations containing hydroalcoholic extract of red propolis

Authors

  • Felipe Oliveira Bittencourt Faculdade Independente do Nordeste - 45055-030, Vitória da Conquista, BA, Brasil.
  • Francine Ferreira Padilha Instituto de Tecnologia e Pesquisa, Universidade Tiradentes, 49032-490, Aracaju, SE, Brasil.
  • Anderson Lessa Siqueira Instituto de Tecnologia e Pesquisa, Universidade Tiradentes, 49032-490, Aracaju, SE, Brasil.
  • Camila Gomes Dantas Instituto de Tecnologia e Pesquisa - Universidade Tiradentes, 49032-490, Aracaju-SE, Brasil.
  • Lucyana Santos de Mendonça Instituto de Tecnologia e Pesquisa, Universidade Tiradentes, 49032-490, Aracaju, SE, Brasil.
  • Yzila Liziane Farias Maia Araújo Instituto de Tecnologia e Pesquisa, Universidade Tiradentes, 49032-490, Aracaju, SE, Brasil.
  • Edílson Divino de Araújo Universidade Federal de Sergipe, 49100-000, Aracaju, SE, Brasil.
  • Juliana Cordeiro Cardoso Instituto de Tecnologia e Pesquisa, Universidade Tiradentes, 49032-490, Aracaju, SE, Brasil.

Keywords:

Antifungal Activity, pharmaceutical semisolid dosage forms, Red Propolis.

Abstract

Red propolis, found in Brazilian Northwest coast, is a new variety of Brazilian propolis and has been studied since 2006, presenting excellent antimicrobial activity. The aim of this work was the development and evaluation of antifungal activity of topical formulations containing red propolis extract. The total of flavonoids found on red propolis extract was 1.8%. The antimicrobial activity was performed against Candida albicans by diffusion method and showed inhibition zone of 13.18 mm ± 2.14 at 600 μg and the minimum fungicidal concentration (MFC) was 647.5 μg/ mL. The formulation was developed using as excipients the Lanette™ cream, Polawax™ cream, Hostacerin™ cream-gel, the Aristoflex™ gel and Natrosol™ gel (hydroxyethylcelullose). The formulation containing red propolis that presented the best stability and antifungal activity (inhibition zone of 16.33 mm ± 0.58) was with Lanette™ cream.

Author Biography

Camila Gomes Dantas, Instituto de Tecnologia e Pesquisa - Universidade Tiradentes, 49032-490, Aracaju-SE, Brasil.

http://lattes.cnpq.br/8964591877480293

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Published

2014-10-08

How to Cite

Bittencourt, F. O., Padilha, F. F., Siqueira, A. L., Dantas, C. G., Mendonça, L. S. de, Araújo, Y. L. F. M., … Cardoso, J. C. (2014). Evaluation of antifungal activity of semisolid formulations containing hydroalcoholic extract of red propolis. Scientia Plena, 10(10). Retrieved from https://scientiaplena.org.br/sp/article/view/1914

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Vol. 10 No. 10 (2014): October/Outubro 2014

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