Antifungal activity of carvacrol and antifungal agent combinations against non-albicans Candida species

Jefferson Rodrigues Nóbrega, Paula Mariane Silva Sousa, Kelly Samara de Lira Mota, Laísa Vilar Cordeiro, Francisco Patricio de Andrade Júnior, Wylly Araújo de Oliveira

Resumo


The aim of this study was to determine the minimum inhibitory concentration of carvacrol and to evaluate the antifungal activity of carvacrol when combinated with fluconazole, ketoconazole or amphotericin B against non-albicans Candida species. MICs were determined using microdilution method, and the combination study was conducted using the checkerboard method. The carvacrol MIC ranged between 128 and 512 μg/mL. The greatest antifungal activity was displayed with ketoconazole. Conversely, fluconazole displayed the lowest activity. Amphotericin B showed MICs ranging from 0.5 to 2 μg/mL. The best combinations were observed against Candida guilliermondii and Candida parapsilosis, which presented synergistic efects. Additive efect was observed in three combinations, whereas, indifferent interactions were seen in six combinations. No antagonistic effects were observed. Based on these results, we conclude that carvacrol retains high activity against non-albicans Candida strains, and the combinations between carvacrol and the antifungals tested yielded significant effects.


Palavras-chave


antifungal, association, terpene.

Texto completo:

PDF (English)


DOI: https://doi.org/10.14808/sci.plena.2019.104601

Apontamentos

  • Não há apontamentos.


Direitos autorais 2019 Jefferson Rodrigues Nóbrega, Paula Mariane Silva Sousa, Kelly Samara de Lira Mota, Laísa Vilar Cordeiro, Francisco Patricio de Andrade Júnior, Wylly Araújo de Oliveira

Licença Creative Commons
Todo conteúdo deste periódico, salvo quando explicitado de forma diferente, está licenciado com uma Licença Creative Commons Atribuição 4.0 Internacional.